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Materials

Poly(Propylene Fumarate)

Most research our lab currently focuses on revolves around the use of the biomaterial called poly(propylene fumarate), or PPF for short. PPF is a linear unsaturated polyester that is biocompatible and has shown promise as a viable scaffold for bone regeneration. The references organized herein have been distilled from work done internal and external to this lab and serve to provide information on the various important and sought after properties of the material.

We have made available a comprehensive EndNotes Library on PPF for Bone Tissue Engineering, which can be downloaded here or in MS-DOC format here.


Additive Manufacturing (colloquially 3D-Printing)

Projection Stereolithography

  • Continuous digital light processing (cDLP): Highly accurate additive manufacturing of tissue engineered bone scaffolds.
  • Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package.
  • Fabrication of 3D biocompatible/biodegradable micro-scaffolds using dynamic mask projection microstereolithography.
  • Rapid fabrication of rigid biodegradable scaffolds by excimer laser mask projection technique: a comparison between 248 and 308 nm.
  • Development of 3D PPF/DEF scaffolds using micro-stereolithography and surface modification.

Stereolithography

  • Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth.
  • Poly(propylene fumarate) bone tissue engineering scaffold fabrication using stereolithography: effects of resin formulations and laser parameters.
  • Fabrication and characteristic analysis of a poly(propylene fumarate) scaffold using micro-stereolithography technology.
  • Rigid biodegradable photopolymer structures of high resolution using deep-UV laser photocuring.
  • Towards excimer-laser-based stereolithography: a rapid process to fabricate rigid biodegradable photopolymer scaffolds.

3D-Printing

  • Fabrication and characterization of poly(propylene fumarate) scaffolds with controlled pore structures using 3-dimensional printing and injection molding.

Fused Deposition Modeling

  • High-precision flexible fabrication of tissue engineering scaffolds using distinct polymers.

Degradation

  • Morphological and histological analysis on the in vivo degradation of poly (propylene fumarate)/(calcium sulfate/β-tricalcium phosphate).
  • In vitro degradation of a poly(propylene fumarate)-based composite material.
  • In vivo degradation of a poly(propylene fumarate)/beta-tricalcium phosphate injectable composite scaffold.
  • In vitro degradation of a poly(propylene fumarate)/ β-tricalcium phosphate composite orthopaedic scaffold.
  • Degradation and biocompatibility of a poly(propylene fumarate)-based/alumoxane nanocomposite for bone tissue engineering.
  • Studies on Poly(propylene fumarate-co-caprolactone diol) Thermoset Composites towards the Development of Biodegradable Bone Fixation Devices

Synthesis

  • Ring-Opening Copolymerization of Maleic Anhydride with Epoxides: A Chain-Growth Approach to Unsaturated Polyesters.
  • Synthesis of poly(propylene fumarate).
  • Poly(propylene fumarate) [patent]
  • Poly(propylene glycol fumarate) compositions for biomedical applications (origin of PPF) [patent]

Polymer Properties

Viscosity

  • Polypropylene fumarate: one example to study the finite length effect on glass transition temperature and polymer dynamics.

Glass Transition

  • Polypropylene fumarate: one example to study the finite length effect on glass transition temperature and polymer dynamics.

Cell Response

  • Distinct cell responses to substrates consisting of poly(ε-caprolactone) and poly(propylene fumarate) in the presence or absence of cross-links.
  • Estimation of cell proliferation by various peptide coating at the PPF/DEF 3D scaffold
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